More than 1.5 million people in the United States get sepsis each year, and sepsis is a leading cause of critical illness and hospital mortality. One in three patients who die in the hospital has sepsis. While anyone can develop sepsis, it is most common and most dangerous in older adults or those with weakened immune systems. Physicians need to know the updated sepsis guidelines, to be better aware of patients at higher risk and to provide optimal care and outcomes through an aggressive multidisciplinary approach.